The Colin Higgins Foundation supports a wide variety of causes furthering HIV/AIDS prevention, education care and harm reduction, and fostering lesbian, gay, bisexual and transgender empowerment. It emphasizes reaching geographically and demographically underserved communities including rural and reservation communities, communities of color, transgender communities, and low-income communities. The foundation is part of Tides Foundation, a larger parent foundation which partners with donors to increase and organize resources for social change.