Parkinson's Disease


	Parkinson's Disease
clonal machina
12-27-2007 3:54 PM
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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/1b182215-c28f-43c4-8454-81a2d076fbe0/72BEA538-795E-46A9-AB9A-8190076CD29A/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1" href="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1" style="font-size: 11px;">biology.plosjournals.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">Midbrain dopamine neurons play important roles in motor control, reward, addiction, attention, and cognition [<A href="#journal-pbio-0050325-b001">1</A>,<A href="#journal-pbio-0050325-b002">2</A>].</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">30% of the population will be over the age of 65 y around 2025 [<A href="#journal-pbio-0050325-b003">3</A>]</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">midbrain dopamine neurons are derived from the floor plate and that foxa2 plays a central role in specifying dopamine neurons.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">he initial deficit is asymmetric and preferentially affects dopamine neurons of the substantia nigra (SN) while leaving the ventral tegmental area (VTA) intact, a pattern of sensitivity also seen in Parkinson patients [<A href="#journal-pbio-0050325-b020">20</A>]</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1">The <EM>foxa2</EM> Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1"><DIV id="hdr">
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</DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0050325&ct=1"><H1>The <EM>foxa2</EM> Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age </H1></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/72BEA538-795E-46A9-AB9A-8190076CD29A/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>
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