Gene therapy could ease chronic pain


	Gene therapy could ease chronic pain

pokkets

1-21-2008 10:17 PM

224 views

tags:

gene, endorphin, chronic, pain

pokkets says:

I wonder why they can't just inject people with endorphins. Or use the same genes to create the endorphins outside the body. Sounds like a sales pitch to get people where it hurts.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/8a37fe1a-305e-44cd-8874-3bbe16172e68/9D4BD664-E09F-4196-ADC0-5CA5769CA835/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest" href="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest" style="font-size: 11px;">www.abc.net.au</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest"><P class="first">An experimental gene therapy treatment has given rats relief from chronic pain for three months, say US researchers.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest"><div align="center"><img src="http://content8.clipmarks.com/blog_cache/www.abc.net.au/img/6EFB0205-61F7-48A9-9ECA-DB9F2F9D1C60" alt="morphine" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest"><P>Dr Andreas Beutler and colleagues at the <A target="_blank" href="http://www.mssm.edu/">Mount Sinai School of Medicine</A> in New York report their findings in this week's issue of the <A target="_blank" href="http://www.pnas.org"><I>Proceedings of the National Academy of Sciences</I></A>.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest"><P>The rats were injected with a gene that tricks the body into releasing endorphins, a natural painkiller, in the nerve cells surrounding the spinal cord. </P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest"><P>The treatment simulates the effect of painkilling drugs but is much narrower in scope, targeting nerve cells along the spinal cord, but not in the brain or in other parts of the central nervous system. </P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest"><P>Researchers are hopeful that the therapy could potentially be used to treat people with severe or chronic pain sparing them some of the debilitating side effects of the opiod drugs currently on the market which act systemically, rather than locally. </P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/01/22/2143676.htm?site=science&topic=latest"><P>The rats, which had an animal version of neuropathic pain, were symptom free for over three months. </P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/9D4BD664-E09F-4196-ADC0-5CA5769CA835/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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