DNA breaks and aging


	DNA breaks and aging

Silkweaver

6-19-2008 7:57 PM

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tags:

genome, molecular biology, aging

2 Comments |

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6-23-2008 5:50 AM

Silkweaver

Not the breaks, but the fixings, or the non fixings to be more accurate.

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/4701aadd-d66f-4fd0-be54-df9fa46897fc/9F1F24BE-2C76-43C1-BFA4-C0586BB14ED3/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/" href="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/" style="font-size: 11px;">ouroboros.wordpress.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/">Do DNA double-strand breaks (DSBs) have anything to do with aging? </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/">We have some reason to believe that they do. in yeast, longevity-enhancing mutations <A genomic-instability-and-transcriptional-noise="" 04="" 12="" 2006="" href="http://ouroboros.wordpress.com/2008/01/18/longevity-mutation-suppresses-genome-instability/
“>suppress genomic instability</a>. Conversely, in the rodent heart, aging animals show evidence of sporadic large-scale <a href="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/linkindex="8" set="yes">genomic rearrangements</A>, which could be caused by misrepair of DSBs. These rearrangements are thought to contribute to transcriptional “noise,” which in turn could explain some age-related decline in tissue function.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/">On the other hand, genomic rearrangements do not always occur as a concomitant of aging, even within the same organism</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/">In the first (written with colleagues Han Li and James Mitchell), the authors argue from genetic evidence that DSB repair pathways are intimately connected with aging</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/">Hasty</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://ouroboros.wordpress.com/2008/06/19/dna-double-strand-breaks-and-aging/">argues that non-homologous end-joining NHEJ), a major pathway of DSB repair, evolved primarily as a means to slow aging — rather than to prevent cancer, as is likely the case for other DNA repair pathways</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/9F1F24BE-2C76-43C1-BFA4-C0586BB14ED3/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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