Levels Of Prion Protein In Brain May Not Be Reliable Marker For Disease


	Levels Of Prion Protein In Brain May Not Be Reliable Marker For Disease

etcrisis

12-24-2007 12:31 AM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/02780822-0e2d-4353-9388-25f6d0e2cb94/B558D6DD-4227-47C6-B6E4-E941D2F637A2/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.sciencedaily.com/releases/2007/11/071130144506.htm" href="http://www.sciencedaily.com/releases/2007/11/071130144506.htm" style="font-size: 11px;">www.sciencedaily.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciencedaily.com/releases/2007/11/071130144506.htm"><P>Rona Barron and colleagues tested whether abnormal PrP and infectivity was an absolute association. They injected mice with two different strains of prion-infected tissue and quantified the degree of infection in these mice. </p> <P>Next, they examined the amount of abnormally folded PrP in brains of the sick mice and found that it did not correlate in any way with how infectious the disease strain was; in fact, some highly infectious tissue samples had nearly undetectable levels of abnormal PrP.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciencedaily.com/releases/2007/11/071130144506.htm">These data suggest that not all abnormal PrP found in diseased tissues is infectious, and may instead be a pathologic by-product of disease.  Some other agent, or a specific conformation of abnormally folded PrP, may therefore be responsible for prion disease</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/B558D6DD-4227-47C6-B6E4-E941D2F637A2/blog/" title="blog or email this clip"><img src="http://content7.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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