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imipramine overdose
jthomasparuch
follow
0
7-18-2008 2:12 PM
47 views
tags:
tcas
,
tca
,
imipramine overdose
,
treatment of antidepressant overdose
,
toxicity
jthomasparuch
says:
-give bicarb which prevents arrythmias by alleviating the cardio-depressant action on sodium channels
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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/17aaa32d-0c5f-42af-bb71-95b1c03cb682/BC1602FB-CF11-4BD0-A172-8ED9100E744A/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="file:///C:/Users/Medicine%20Man/Desktop/Backup%20files%20from%20old%20laptop/Backup%20Files/USMLE%20WORLD%202007/int.medcine/biostatics,ent,opth,preventive,toxins.psychatery/toxins/Test37_Poi_R/Question%201%20of%2014_files/qstLoad.htm" href="file:///C:/Users/Medicine%20Man/Desktop/Backup%20files%20from%20old%20laptop/Backup%20Files/USMLE%20WORLD%202007/int.medcine/biostatics,ent,opth,preventive,toxins.psychatery/toxins/Test37_Poi_R/Question%201%20of%2014_files/qstLoad.htm" style="font-size: 11px;"></a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="file:///C:/Users/Medicine%20Man/Desktop/Backup%20files%20from%20old%20laptop/Backup%20Files/USMLE%20WORLD%202007/int.medcine/biostatics,ent,opth,preventive,toxins.psychatery/toxins/Test37_Poi_R/Question%201%20of%2014_files/qstLoad.htm"><P><DIV>Sodium bicarbonate is the single most effective intervention in the management of TCA intoxication. This agent helps to reverse QRS prolongation, which is associated with TCA intoxication. It prevents development of arrhythmia by alleviating cardio depressant action on sodium channels. Other useful effects are by reversing acidosis associated with TCA overdose. However, sodium bicarbonate is even beneficial at normal pH. Alkalinization of urine is not the reason for the beneficial effect of sodium bicarbonate in TCA intoxication. </DIV><BR /><B>Educational Objective</B>:<BR />Sodium bicarbonate prevents the development of arrhythmia in patients with tricyclic antidepressant toxicity by alleviating cardio-depressant action on sodium channels.</P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;"> </td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/BC1602FB-CF11-4BD0-A172-8ED9100E744A/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>
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