genetic risk for statin induced myopathy

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	genetic risk for statin induced myopathy

Sophios33

10-17-2009 10:02 PM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/5deebe82-832a-40cc-aa18-31827785f00d/C6195DC1-F8A9-488A-8D65-3050D7A7C5F6/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://cme.medscape.com/viewarticle/707879_10" href="http://cme.medscape.com/viewarticle/707879_10" style="font-size: 11px;">cme.medscape.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://cme.medscape.com/viewarticle/707879_10">The incidence of rhabdomyolysis is higher (4.2 per 100,000 person-years) with lovastatin, simvastatin, or atorvastatin, statins that are oxidized by the cytochrome P450 3A4, than with pravastatin or fluvastatin, which are not oxidized by the cytochrome P450 3A4. This pathway is inhibited by many drugs, and in fact one of the proposed mechanisms leading to myopathy is increased serum concentrations.<SUP><A href="javascript:newshowcontent('active','references');">[28,29] </A></SUP>The incidence of myopathy is also increased in patients on higher statin doses (eg, simvastatin 80 mg/day) compared to patients on lower doses (eg, simvastatin 40 mg/day).<SUP><A href="javascript:newshowcontent('active','references');">[30] </A></SUP>In addition, the rs4363657 SNP located within <EM>SLCO1B1 </EM>on chromosome 12 has recently been reported to be associated with an increased risk for statin-induced myopathy. <EM>SLCO1B1 </EM>encodes for an organic anion-transporting polypeptide OATP1B1 that regulates the hepatic uptake of statins.<SUP><A href="javascript:newshowcontent('active','references');">[30]</A></SUP></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/C6195DC1-F8A9-488A-8D65-3050D7A7C5F6/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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