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How to Check Yourself for Genetic Abnormalities
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7-8-2008 10:00 AM
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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/157ae079-dc8e-4084-9397-5a505ca2ba71/C8BCAF65-1B9A-434E-93BF-DA411A5D64B9/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072" href="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072" style="font-size: 11px;">howto.wired.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H2> <SPAN class="mw-headline">Option 1: Visit a Genetic Counselor</SPAN></H2></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072">To find a good one, visit the <A title="http://www.nsgc.org/zip_search/index.cfm" class="external text" href="http://www.nsgc.org/zip_search/index.cfm">National Society of Genetic Counselors</A> website. </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H2> <SPAN class="mw-headline">Option 2: Scan Your Whole Genome</SPAN></H2></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><DIV class="thumbinner"><A title="23andMe's webapp" class="image" href="http://howto.wired.com/wiki/Image:23andme_webapp.png"><IMG width="200" height="140" border="0" class="thumbimage" src="http://howto.wired.com/mediawiki/images/thumb/23andme_webapp.png/200px-23andme_webapp.png" alt="23andMe's webapp" /></A> <DIV class="thumbcaption"><DIV class="magnify"><A title="Enlarge" class="internal" href="http://howto.wired.com/wiki/Image:23andme_webapp.png"><IMG width="15" height="11" alt="" src="http://howto.wired.com/mediawiki/skins/common/images/magnify-clip.png" /></A></DIV>23andMe's webapp</DIV></DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H2> <SPAN class="mw-headline">Option 3: Perform Lab Tests at Home</SPAN></H2></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H3> <SPAN class="mw-headline">Why do it the hard way?</SPAN></H3></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H3> <SPAN class="mw-headline">Step 1: Swab some cells from your cheek</SPAN></H3></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H3> <SPAN class="mw-headline">Step 2: Extract DNA from those cells</SPAN></H3></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H3> <SPAN class="mw-headline">Step 3: Design and Order PCR primers and controls</SPAN></H3></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H3> <SPAN class="mw-headline">Step 4: Copy the DNA with the PCR reaction</SPAN></H3></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><DIV class="thumbinner"><A title="A DNA Engine Dyad thermocycler" class="image" href="http://howto.wired.com/wiki/Image:DNA_engine.jpg"><IMG width="200" height="137" border="0" class="thumbimage" src="http://howto.wired.com/mediawiki/images/thumb/DNA_engine.jpg/200px-DNA_engine.jpg" alt="A DNA Engine Dyad thermocycler" /></A> <DIV class="thumbcaption"><DIV class="magnify"><A title="Enlarge" class="internal" href="http://howto.wired.com/wiki/Image:DNA_engine.jpg"><IMG width="15" height="11" alt="" src="http://howto.wired.com/mediawiki/skins/common/images/magnify-clip.png" /></A></DIV>A DNA Engine Dyad thermocycler</DIV></DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><H3> <SPAN class="mw-headline">Step 5: Sequence the amplified genetic material</SPAN></H3></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><DIV class="thumbinner"><A title="You'll need a cloning kit" class="image" href="http://howto.wired.com/wiki/Image:Cloning_kit.jpg"><IMG width="200" height="142" border="0" class="thumbimage" src="http://howto.wired.com/mediawiki/images/thumb/Cloning_kit.jpg/200px-Cloning_kit.jpg" alt="You'll need a cloning kit" /></A> <DIV class="thumbcaption"><DIV class="magnify"><A title="Enlarge" class="internal" href="http://howto.wired.com/wiki/Image:Cloning_kit.jpg"><IMG width="15" height="11" alt="" src="http://howto.wired.com/mediawiki/skins/common/images/magnify-clip.png" /></A></DIV>You'll need a cloning kit</DIV></DIV></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://howto.wired.com/wiki/Check_Yourself_for_Genetic_Abnormalities?oldid=40072"><LI class="toclevel-1"><A href="#Option_1:_Visit_a_Genetic_Counselor"><SPAN class="tocnumber">1</SPAN> <SPAN class="toctext">Option 1: Visit a Genetic Counselor</SPAN></A></LI> <LI class="toclevel-1"><A href="#Option_2:_Scan_Your_Whole_Genome"><SPAN class="tocnumber">2</SPAN> <SPAN class="toctext">Option 2: Scan Your Whole Genome</SPAN></A></LI> <LI class="toclevel-1"><A href="#Option_3:_Perform_Lab_Tests_at_Home"><SPAN class="tocnumber">3</SPAN> <SPAN class="toctext">Option 3: Perform Lab Tests at Home</SPAN></A> <UL> <LI class="toclevel-2"><A href="#What_You.27ll_Need"><SPAN class="tocnumber">3.1</SPAN> <SPAN class="toctext">What You'll Need</SPAN></A></LI> <LI class="toclevel-2"><A href="#Why_do_it_the_hard_way.3F"><SPAN class="tocnumber">3.2</SPAN> <SPAN class="toctext">Why do it the hard way?</SPAN></A></LI> <LI class="toclevel-2"><A href="#Step_1:_Swab_some_cells_from_your_cheek"><SPAN class="tocnumber">3.3</SPAN> <SPAN class="toctext">Step 1: Swab some cells from your cheek</SPAN></A></LI> <LI class="toclevel-2"><A href="#Step_2:_Extract_DNA_from_those_cells"><SPAN class="tocnumber">3.4</SPAN> <SPAN class="toctext">Step 2: Extract DNA from those cells</SPAN></A></LI> <LI class="toclevel-2"><A href="#Step_3:_Design_and_Order_PCR_primers_and_controls"><SPAN class="tocnumber">3.5</SPAN> <SPAN class="toctext">Step 3: Design and Order PCR primers and controls</SPAN></A></LI> <LI class="toclevel-2"><A href="#Step_4:_Copy_the_DNA_with_the_PCR_reaction"><SPAN class="tocnumber">3.6</SPAN> <SPAN class="toctext">Step 4: Copy the DNA with the PCR reaction</SPAN></A></LI> <LI class="toclevel-2"><A href="#Step_5:_Sequence_the_amplified_genetic_material"><SPAN class="tocnumber">3.7</SPAN> <SPAN class="toctext">Step 5: Sequence the amplified genetic material</SPAN></A></LI></UL></LI></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;"> </td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/C8BCAF65-1B9A-434E-93BF-DA411A5D64B9/blog/" title="blog or email this clip"><img src="http://content7.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>
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