Viral Recombination: Another Way HIV Fools The Immune System


	Viral Recombination: Another Way HIV Fools The Immune System

tabsey

7-23-2008 9:30 AM

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tags:

knowledge, understanding, education

tabsey says:

One big battle for the scientists. Humans don't seem to want to avoid, or even want to know. (I suppose the best present a rape victim can give to the assailant is HIV.)

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/362a0461-180f-48f8-b864-d87a92fa44c6/C95305E2-54BD-4A34-8F46-53CFDF55BB1A/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.sciencedaily.com/releases/2008/07/080721151941.htm" href="http://www.sciencedaily.com/releases/2008/07/080721151941.htm" style="font-size: 11px;">www.sciencedaily.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciencedaily.com/releases/2008/07/080721151941.htm"><P id="first"><SPAN class="date">ScienceDaily (July 23, 2008)</SPAN> — When individuals infected with HIV become infected with a second strain of the virus, the two viral strains can exchange genetic information, creating a third, recombinant strain of the virus.  It is known that the presence of multiple viral strains, called superinfection, frequently leads to a loss of immune control of viral levels.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciencedaily.com/releases/2008/07/080721151941.htm"><P>Now a study from the Partners AIDS Research Center at Massachusetts General Hospital (PARC/MGH) shows that how and where viral strains swap DNA may be determined by the immune response against the original infecting strain. </P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.sciencedaily.com/releases/2008/07/080721151941.htm"><P>"The implication that recombination events are selected by immune responses identifies a new mechanism for the virus to escape the patient's immune system, which would present additional challenges to vaccine design," says Hendrik Streeck, MD, PhD, of PARC/MGH, one of the paper's lead authors. "This finding also has worldwide implications for the development of more complex strains of HIV."</P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/C95305E2-54BD-4A34-8F46-53CFDF55BB1A/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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