Low cerebrospinal fluid (CSF) levels of hypocretin are diagnostic for narcolepsy.


	Low cerebrospinal fluid (CSF) levels of hypocretin are diagnostic for narcolepsy.

fewstingscorpio

7-1-2008 10:38 PM

205 views

tags:

narcolepsy, "sleep disorders", cataplexy, health, research, hypocretin, "cerebrospinal fluid", neurology

fewstingscorpio says:

A little prick in the back goes a long way...Sounds like a good tool if you happen to be having one anyway.
For the whole article in it's entirety:
http://www.medscape.com/viewarticle/443623

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/5e212881-f67e-4030-93ad-b1ea534ffb0f/CE8B0AE2-2151-4EA4-8053-0014453B571E/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.medscape.com/viewarticle/443623" href="http://www.medscape.com/viewarticle/443623" style="font-size: 11px;">www.medscape.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medscape.com/viewarticle/443623">Low cerebrospinal fluid (CSF) levels of hypocretin are diagnostic for narcolepsy,</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medscape.com/viewarticle/443623">Because hypocretin neurons are positioned to drive monoaminergic activity across the sleep cycle, loss of this excitatory input may explain the abnormalities seen in narcolepsy. </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medscape.com/viewarticle/443623">n this case series of 274 patients with sleep disorders seen in specialty clinics from 1999 to 2002, diagnoses included narcolepsy, hypersomnia, obstructive sleep apnea, restless legs syndrome, insomnia, and atypical hypersomnia cases such as familial cases, narcolepsy without cataplexy or without HLA-DQB1*0602, recurrent hypersomnias, and symptomatic cases secondary to Parkinson disease, depression, Prader-Willi syndrome, or Niemann-Pick disease type C. The subject group also included 296 controls </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medscape.com/viewarticle/443623">either healthy or who had neurological disorders.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.medscape.com/viewarticle/443623"><P>Frequency of HLA type HLA-DQB1*0602 was increased in narcolepsy with typical cataplexy (93% vs. 17% in controls), narcolepsy without cataplexy (56%), and in essential hypersomnia (52%). </P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/CE8B0AE2-2151-4EA4-8053-0014453B571E/blog/" title="blog or email this clip"><img src="http://content8.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>