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Antidepressant vs. placebo
deanknows
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4
6-12-2007 11:53 PM
567 views
tags:
psychology
,
antidepressants
,
depression
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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/a6ceb830-1db6-41ec-8172-bf4380ac3478/D5C98C76-599F-472B-93F8-4477F5D949BC/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm" href="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm" style="font-size: 11px;">web.archive.org</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm">The placebo effect is itself quite strong. As many as 30% to 50% of patients who receive a placebo will recover from their depression if they are convinced they have received a real antidepressant.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm">This explains why so many people will protest and say, "but I took Prozac (or Paxil or whatever) and it worked miracles for me! So I know these drugs work!</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm">But remember that 30% to 50% of mildly to moderately depressed patients will also recover if they are given a placebo--so how do we know these aren't just placebo responses? I</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm">In nearly all drug company studies of new (or old) antidepressants, all patients are first placed on a placebo for a one or two week period.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm">Those who show an improvement in depression are removed from the study.</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm">In this way, drug companies remove the "placebo responders:" before the actual study begins. This is like playing with a stacked deck,</blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://web.archive.org/web/20030420165521/feelinggood.com/Guru+Questions/questions+of+the+week+2/wednesday+answer+4.htm">because it creates a bias in which it will appear that the drug is better than placebo</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;"> </td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/D5C98C76-599F-472B-93F8-4477F5D949BC/blog/" title="blog or email this clip"><img src="http://content7.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>
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