Scientists find malaria's 'sticky' genes


	Scientists find malaria's 'sticky' genes

einbar

7-9-2008 3:50 PM

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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/ff8f4609-8d50-4949-a69f-eb1581eeca2e/EDC22FF1-4065-4E9C-B8D9-9A4A8AD0A148/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest" href="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest" style="font-size: 11px;">www.abc.net.au</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest">
<H1><SPAN>Scientists find malaria's 'sticky' genes</SPAN></H1></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest"><P>Australian scientists have identified a potential new way of combating the global scourge of malaria, by pinpointing eight genes that help the disease-causing parasite remodel our red blood cells.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest">
<P>Blood cells infected by the malaria parasite lose their normal rigid shape 
and develop knobs on their surface, causing them to stick to blood vessel walls 
and stop circulating smoothly.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest">This stops the cells from being cleared by the spleen, which is a protective 
mechanism for the parasite," Cowman says. "It's absolutely </blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest"><P>By genetically manipulating <EM>Plasmodium falciparum</EM> - the most severe form of malaria parasite - the researchers were able to identify eight genes that produce proteins needed to change the cells in this way.</P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.abc.net.au/science/articles/2008/07/09/2298716.htm?site=science&topic=latest"><P><P>It is also possible that </P><P></P>researchers could use their new understanding to develop weakened forms of the parasite to use in a vaccine against the disease, he says.</P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/EDC22FF1-4065-4E9C-B8D9-9A4A8AD0A148/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

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