<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://www.clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/0e0268d2-a14f-41c2-91d8-7be320716baa/F660436F-FDEC-4640-92EB-25385EFD3CC7/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://www.biomedcentral.com/1471-2164/9/291" href="http://www.biomedcentral.com/1471-2164/9/291" style="font-size: 11px;">www.biomedcentral.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://www.biomedcentral.com/1471-2164/9/291"><P>Genes involved in transcription and translation, ribosomal and mitochondrial biogenesis and stress response appear to be up-regulated by phagocytosis. This is not surprising, as cells grow on bacteria more rapidly than in axenic medium, therefore it is likely that phagocytosis triggers gene expression changes leading to increased ribosomal and mitochondrial biogenesis as well as protein synthesis. A total of six genes encoding heat shock proteins (HSP), including HSP 70 family protein (<EM>hspN</EM>, DDB0186670) are up-regulated among genes induced by phagocytosis (cluster 1/5/7) and genes induced by phagocytosis and growth (cluster 4). Two of them (<EM>grpE</EM>, DDB0185728 and <EM>cpn10A</EM>, DDB0187651) encode chaperonins involved in mitochondrial transport and their up-regulation could be linked to increased mitochondrial biogenesis. HSP's have been shown to modulate inflammatory response and phagocytosis in macrophages, though their mechanism of action remains unknown <A name="IDA23VXDB"></A><A name="IDA53VXDB"></A>[<A href="#B52">52</A>,<A href="#B53">53</A>].</P></blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;">&nbsp;</td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/F660436F-FDEC-4640-92EB-25385EFD3CC7/blog/" title="blog or email this clip"><img src="http://content6.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>

New from the makers of Clipmarks:  Amplify.com - Don't just share the news...Amplify it!