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POPS Neuronal Computations Governing Strategic Social Interactions in the Human Brain Furthermore, a number of brain areas previously implicated in mentalizing, such as the superior temporal sulcus (STS) and medial prefrontal cortex (mPFC), showed changes in their activity over time. These changes are predicted by the mathematical model, suggesting that the brain itself uses mathematical operations similar to that encapsulated in the model to solve the task.