35
POPS25 Greatest Science Books of All Time The Origin of Species (1859) Darwin's masterwork is, undeniably, The Origin of Species , in which he introduced his theory of evolution by natural selection. Prior to its publication, the prevailing view was that each species had existed in its current form since the moment of divine creation and that humans were a privileged form of life, above and apart from nature. Darwin's theory knocked us from that pedestal. Wary of a religious backlash, he kept his ideas secret for almost two decades while bolstering them with additional observations and experiments. The result is an avalanche of detail—there seems to be no species he did not contemplate—thankfully delivered in accessible, conversational prose. A century and a half later, Darwin's paean to evolution still begs to be heard: "There is grandeur in this view of life," he wrote, that "from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved."
32
POPSThe Coming Death Shortage "Why the longevity boom will make us sorry to be alive" a must read. Though I fail to agree with many of the premises of this article, the critical views it presents are important and the issues need be taken into consideration seriously
31
POPSHomosexual behavior due to genetics and environmental factors “Overall, genetics accounted for around 35 per cent of the differences between men in homosexual behavior and other individual-specific environmental factors (that is, not societal attitudes, family or parenting which are shared by twins) accounted for around 64 per cent. In other words, men become gay or straight because of different developmental pathways, not just one pathway.” For women, genetics explained roughly 18 per cent of the variation in same-sex behavior, non-shared environment roughly 64 per cent and shared factors, or the family environment, explained 16 per cent. The study shows that genetic influences are important but modest, and that non-shared environmental factors, which may include factors operating during fetal development, dominate.
29
POPSMichael Phelps: ‘Naturally’ transhuman
* He has proportionately short legs relative to his long, powerful trunk; this large upper body is the engine that powers his long arms. Moreover, his unique physique reduces drag through the water and allows for maximum propulsion. * Phelps has a greater-than-average lung capacity allowing him to execute his underwater dolphin kicks longer than the competition. * He has a genetic advantage that cause his muscles to produce 50% less lactic acid than other athletes. This means he can work at higher work loads for longer periods. * With a low body fat of 4%, he is better able to convert his effort into speed. Looking at this list it’s as if Phelps was designed to swim. Which leads to an interesting question: Given the potential for genetic modification and gene doping, should it be acceptable for other athletes to acquire the same physiological endowments through artificial means? If not, what makes it so acceptable to come by these traits ‘naturally?’ And how
27
POPSZebra's Stripes, Butterfly's Wings: How Do Biological Patterns Emerge? Previous work identified a specific signal necessary for getting these fly egg cells to move; the problem is that this signal is “graded.” Like drops of ink spreading out on wet paper, this signal travels in between surrounding cells, gradually fading away as it moves outwards. But clear lines are required for pattern formation — there is no grey area between a zebra’s black and white stripes, between heart and liver cells and, in this case, between migrating cells and those that stay put. How are graded signals converted to a clear move or stay signal? By examining flies containing mutations in different genes, the researchers discovered that one gene in particular, called apontic, is important for converting a graded signal.
27
POPSMan Made Life Whoa. The implications from this will be enormous. If this project succeeds expect a concerted campaign of denial and attack from the religious conservatives.
25
POPSThinking ahead: Bacteria anticipate coming changes in their environment To test this idea, the researchers exposed a population of E. coli to different temperatures and oxygen changes, and measured the gene responses in each case. The results were striking: An increase in temperature had nearly the same effect on the bacterium's genes as a decrease in oxygen level. Indeed, upon transition to a higher temperature, many of the genes essential for aerobic respiration were practically turned off. To prove that this is not just genetic coincidence, the researchers then grew the bacteria in a biologically flipped environment where oxygen levels rose following an increase in temperature. Remarkably, within a few hundred generations the bugs partially adapted to this new regime, and no longer turned off the genes for aerobic respiration when the temperature rose.
24
POPSBrain Imaging Helps Explain Behavior The fMRI study showed that, during the viewing of angry faces, the activity of a structure called the insula, involved in the response to unpleasant situations, depended on which version of the CREB1 gene a participant inherited. “We were surprised to see that variation in the CREB1 gene would account for more than 20 percent of the difference in how healthy participants weighed different options and expressed specific preferences,”
22
POPSPossible 'Sleep Gene' Identified When closed, the channel shuts down and the fly sleeps. The insomniac fruit flies had less of the Sleepless-produced protein. The lack of sleep didn't come without consequences. The Sleepless fruit flies lived about half as long as fruit flies that did not carry the mutation. They also experience impaired coordination and restlessness in their few hours of sleep.
22
POPSDrug tries to offset 10,000 years of evolution Gene therapies, expected some time between 2015 and 2020, promise to correct this genetic problem caused by nature, but many obese people do not want to wait. They are hoping that Nastech’s new nasal spray can provide a solution now. Within 20 to 35 minutes after taking a whiff, this new drug moves quickly through the nasal lining and into the bloodstream, sending a message to the brain that our tummy is full. So far the drug has had no negative side effects. PYY is undergoing clinical trials now, and is expected to be in drug stores by 2009 or 2010. Obesity is the 2nd leading cause of preventable death in America, so this drug offers a great chance for more people to improve their health and get ready to enjoy our “magical future”.
21
POPSSimple reason helps males evolve more quickly “There’s a health aspect in figuring out differences in gene expression between the sexes,” said Wayne. “To make a male or a female, even in a fly, it’s all about turning things on -- either in different places or different amounts or at different times -- because we all basically have the same starting set of genes.”
21
POPSEarth 2030 - healthier, safer, more enjoyable Forward-thinkers believe that by 2035, memories, personality, and feelings ¬ non-physical elements that describe a human being ¬ could be scanned and uploaded into a robot, or newly-cloned human body, enabling life to continue indefinitely.
20
POPSsteven wright's words 18 - Hard work pays off in the future, laziness pays off now. 20 - If Barbie is so popular, why do you have to buy her friends? 21 - Eagles may soar, but weasels don't get sucked into jet engines. 22 - What happens if you get scared half to death twice? 23 - My mechanic told me, "I couldn't repair your brakes, so I made your horn louder." 24 - Why do psychics have to ask you for your name? 25 - If at first you don't succeed, destroy all evidence that you tried. 26 - A conclusion is the place where you got tired of thinking. 27 - Experience is something you don't get until just after you need it. 28 - The hardness of the butter is proportional to the softness of the bread. 29 - To steal ideas from one person is plagiarism; to steal from many is research. 30 - The problem with the gene pool is that there is no lifeguard. 31 - The sooner you fall behind, the more time you'll have to catch up. .