Wales' chief medical officer has warned that more swine-flu related deaths are inevitable as he confirms a fourth death over the past week.
Two women, including a young mother, have also died from the virus in recent days.
Dr Tony Jewell said higher risks groups included young children, pregnant women and those with underlying conditions.
After only one swine flu-related death over the summer, the latest cases have come in quick succession.
One of the victims confirmed over the last week was a 21-year-old mother from Monmouthshire.
The pregnant woman was admitted to Nevill Hall Hospital, Abergavenny, for a planned caesarean section on 25 September.
BBC Wales' health correspondent Hywel Griffiths said the number of cases of people reporting flu-like symptoms stood at around 1,400.