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Serenoa repens: The Scientific Basis for the Treatment of Benign Prostatic Hyperplasia

Fouad K. HabibCorresponding Author Contact Information, a, E-mail The Corresponding Author

aProstate Research Group, School of Medicine, University of Edinburgh, Edinburgh, Scotland, UK

Medical therapies derived from natural sources have been used for centuries. Many are as effective as synthetic medications. The use of plant-derived medications for benign prostatic hyperplasia (BPH) is no exception. In particular, extracts of Serenoa repens (SrE), the fruit of the American dwarf palm, are widely available, and their use is rising throughout the world.

Serenoa repens (saw palmetto) extracts are complex mixtures of compounds that act simultaneously on several biologic pathways known to be associated with the development of benign prostatic hyperplasia (BPH) in man. Reversal of the prohyperplastic pathways by the drug accounts for its clinical efficacy in the treatment of BPH.

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