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POPSEmpty Promises Many effects of antidepressants seem to be due to the placebo effect. And the published trials are only the tip of the iceberg of material that normally doesn't see the light of day. There are also clinical trials that have not been published. These are studies that have failed to show a significant benefit from taking the drug. When all of the data sets are combined " published and unpublished " the inescapable conclusion is that antidepressants may be little more than active placebos, drugs with very little specific therapeutic benefit, but with serious side effects. Not only this, but antidepressants are liberaly prescribed to treat very mild symthoms that rarely stand to the criteria of clinical depression. This does not make the drugs' effectiveness clearer.