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POPSNew BSE cases blamed on ineffective feed ban New BSE cases blamed on ineffective feed ban Edmonton Journal - Edmonton,Alberta,Canada Banning ruminant-to-ruminant feed reduces the chance of cattle ingesting the abnormal, disease-causing prion that causes the disease.
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POPSVendors Hesitate to Sell US Beef Vendors Hesitate to Sell US Beef 코리아타임즈 - South Korea ... likely to contract variant Creutzfeld Jacob Disease (vCJD) • thought to be caused by prion transmission from BSE infected cows than Westerners
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POPSNew Clues to Prion Infectivity The ramifications are primarily this: This is evidence of why CJD has received misdiagnoses so frequently. Cases of Alzheimer's and other degenerative diseases are likely to be later identified as as Mad Cow or CJD. Where'd I learn this? Check out my Blog and find out www.OkieLogic.com
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POPSBeef eaters beware -- safety may be sent packing by Courtney Haden Creekstone sued the USDA in 2006, and in the case of David v. Goliath, the little guy unaccountably won. A decision handed down by a U.S. district judge in March decreed that Creekstone must be permitted to start its own testing June 1. However, thanks to its Hail Mersey call last week, the USDA can appeal the ruling and prevent Creekstone from testing indefinitely.
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POPSMeatpacking Faux Pas If testing is allowed at Creekstone, we think it would become the international standard and the domestic standard, too.
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POPSPrivate BSE testing on hold following appeal Scientists believe that the human illness, Variant Creutzfeldt-Jakob Disease (vCJD) - recognised in 1996 - is caused by the consumption of BSE-infected meat. About 160 people are thought to have died of the condition worldwide.
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POPSPrioNet Canada: prion network join in PrioNet Canada is a Network of Centres of Excellence for research on Bovine Spongiform Encephalopathy, commonly known as mad cow disease, and other Transmissible Spongiform Encephalopathies or prion diseases. The PrioNet Canada web site was built to serve as a portal for members and non-members alike, to access the latest findings in prion science and to discover the wealth of possibilities provided by the network concept. Prion Video Watch a short video on prions produced by the Alberta Prion Research Institute. PrioNews Read the Jan-March 2007 issue of PrioNet's newsletter. Mad Cow Mysteries Science journalist Jay Ingram is hosting a four-city prion public lecture series this month. Register now in your city! High Impact Fund PrioNet Canada establishes fund to support research urgencies in real-time BSE/TSE events.
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POPSSmall regions within prion proteins regulate their ability to cross species barriers
PRINCIPAL INVESTIGATOR Susan Lindquist, Whitehead Institute http://www.wi.mit.edu/research/faculty/lindquist.html Written by David Cameron Susan Lindquist’s primary affiliation is with Whitehead Institute of Biomedical Research, where her laboratory is located and all her research is conducted. She also is a professor of biology at Massachusetts Institute of Technology and a Howard Hughes Medical Institute investigator. "Prion recognition elements govern nucleation, strain specificity and species barriers" Peter M. Tessier (1) & Susan Lindquist (2) (1) Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. (2) Howard Hughes Medical Institute, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA. Advance online publication at www.nature.com at 1 pm U.S. Eastern time, May 9, 2007. Advance online publication digital object identifier: 10.1038/nature05848. This resea
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POPSScientists Identify Prion's Infectious Secret But prions have another characteristic that enables them to wreak havoc. They recruit other, properly folded proteins into misforming along with them, a process Lindquist calls a "conformational cascade." In many organisms, this conformational cascade creates long fibers called amyloids. (The brains of animals that have died from prion infections are literally packed with amyloid clumps.)
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POPSBSE CASE CONFIRMED IN BC More recently (April 2007) was found that; Alzheimer's disease, Parkinson's disease, type II diabetes, the human version of mad cow disease and other degenerative diseases are more closely related at the molecular level. An international team of chemists and molecular biologists reported; „A mystery on which the new Nature paper sheds light is what causes different strains of prions (infectious proteins) in which the protein sequence is identical. Our research gives a strong hypothesis that the origin of prion strains is encoded in the packing of the molecules in the fibrils which we are seeing in the crystals…“
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POPSSpiroplasmas, are present in the hemolymph of almost all insects; there probably are several million Spiroplasmas are also within the size range of the agent that transmits CJD and other transmissible Spongiform encephalopathies. Spiroplasmas will pass through a 50 nm-pore filter. The transmissible agent's size has been determined to be 42 nm.Spiroplasmas, are present in the hemolymph of almost all insects; there probably are several million strains. They can also cause diseases in plants but are usually associated with a vector. For example, a leaf hopper carries a spiroplasma that infects orange trees.
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POPSNews-Medical.Net 'Understanding how rogue prions kill cells is crucial to learning more about the prion diseases that remain a major concern for public and animal health following the BSE epidemic in UK cattle and the emergence of its human counterpart variant CJD. This work forms part of a major research strategy at the MRC Prion Unit to translate basic research findings into potential treatments in the years ahead. The underlying mechanism by which rogue prion proteins disrupt the UPS may be of wider relevance in understanding how misshaped proteins cause other disorders too, like Alzheimer's disease.''
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POPSColony Collapse Disorder Universal Prion 19 Aug 99 webmaster Could a bee sting cause scrapie? Yes, indeed -- there was an apparent near miss 23.6 million years ago in a common ancestor of sheep and cow -- a retrotransposon event that might have boosted prion protein production to levels fostering sporadic TSE. Ruminants contain a 1220 bp mariner retrotransposon in their 3' UTR portion of their mRNA. This element, with its terminal inverted repeats, are described by Lee as a fossil transposase pseudogene with homology to the Mellifera (bee) subfamily. It is probably an old insertion shared by all ruminants since it has 7-8 frameshifts and 5 stop condons -- figure 3 of the Lee paper shows a guided translation and the correct flanking human gene alignment. The insertion in cow/sheep occured between 27587 and 27588 in terms of human 3' UTR numbering, just downstream of the Bov-tA3, greatly increasing the length of ruminant mRNA.
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